Could coffee be the liquid key to longevity?
A new study reports that the most widely used stimulant in the world can extend your life and affect the response of cells to genetic damage, although there is a possible complication.
A team of Queen Mary University in London confirms that caffeine interacts with systems that influence aging, DNA response and cell stress.
The team studied except for Fission, a unicellular body that is analogous to human cells and uses similar routes to manage energy, DNA repair and stress.
Researchers measured the response of fission to different forms of cell stress, including DNA damage, toxic exposure and nutrient deprivation.
Caffeine then added to evaluate how the cells would respond.
They found that while caffeine extended the life of yeast, it also affected how cells responded to stress, especially when the molecular systems that regulate stress were already activated.
The findings were published this week in Microbial Cell Magazine.
The research team previously stated that caffeine supports the longevity of cells by activating Tor (rapamycin goal), a biological switch that determines when cells have to grow based on the availability of food and energy.
According to the team, switch Tor actively controls energy and stress responses in living things for more than 500 million years.
In the latter study, the team learned that caffeine does not activate it directly Tor, but that it influences it by activating AMPK, a cellular fuel reserve on yeast and humans.
“When the cells have low energy, AMPK occurs to help them to face them,” said the author of the Senior Study Charalampos (Babis) Rallis. “And our results show that caffeine helps fly this change.”
The yeast model showed that the influence of caffeine on the vault that the switch directly affects the creation of the cells, repairs its DNA and responds to stress, all related to aging.
Very amazing, the team found that instead of protecting damaged DNA, caffeine amplified the damage.
Usually, when a cell detects DNA damage, it stops dividing it to repair it. However, researchers found that caffeine annuls this stop, allowing non -cured cells to continue to divide and make them more vulnerable to future damage.
The team said that this does not make your morning cup inherently dangerous. The capacity of caffeine to alter the response of cells to problems can be positive or negative, depending on the situation.
The team said that the benefits of caffeine depend on the presence of specific proteins and paths. The fact that the effects of caffeine are not universal or automatic can help explain why previous studies explore the bond between caffeine and improved health have been inconsistent.
“These findings help to explain why caffeine can be beneficial to health and longevity,” said John-Patrick Alao, the postdoctoral research scientist at the head of this study. “And they open exciting possibilities for future research on how we could trigger these effects more directly: with diet, lifestyle or new medicines.”
The team acknowledged that since the study was only based on fission yeast, findings may not be translated directly into human cells.
The coffee has long been praised for its health benefits.
Rich in antioxidants, it can improve brain function. It has also been shown to increase alert, weight management aid, increase mood and reduce the risk of type 2 diabetes and heart disease.
A 2018 study of almost half a million British adults found that coffee drinkers had a slightly inferior risk of death for 10 years than abstainers.
Other investigations that cover More than 170,000 adults in the United Kingdom proposed that those who drink between two and four cups of coffee daily, regardless of whether they have added sugar, live longer than those who do not drink coffee.
A 2025 study led by researchers at the University of Tulane linked a morning beer to lower mortality rates than I exposed later than the day.
And three to five cups a day in the middle life was associated with a decrease in the risk of Alzheimer’s disease later in life, determined the research.
In addition to Alzheimer’s, some studies found that Java Brossa is at risk of 60% lower than Parkinson’s disease.
The more coffee they drank, the lower the risk.
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